期刊
TRENDS IN MOLECULAR MEDICINE
卷 26, 期 1, 页码 89-104出版社
CELL PRESS
DOI: 10.1016/j.molmed.2019.04.008
关键词
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资金
- National Key Research and Development Program of China [2017YFA0104900]
- Post-doctoral Innovative Talents Support Program of China [BX20190380]
- State Scholarship Fund of China [201603170205]
Mitochondria have emerged as key contributors to the organismal homeostasis, in which mitochondrial regulation of stem cells is becoming increasingly important. Originated from mesenchymal stem cell (MSC) and hematopoietic stem cell (HSC) lineage commitments and inter actions, bone is a representative organ where the mitochondrial essentiality to stem cell function has most recently been discovered, underlying skeletal health, aging, and diseases. Further more, mitochondrial medications based on modulating stem cell specification are emerging to provide promising therapies to counteract bone aging and pathologies. Here we review the cutting-edge knowledge regarding mitochondrial regulation of stem cells in bone homeostasis, highlighting mechanistic insights as well as mitochondrial strategies for augmented bone healing and tissue regeneration.
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