期刊
TRENDS IN BIOTECHNOLOGY
卷 37, 期 12, 页码 1295-1314出版社
CELL PRESS
DOI: 10.1016/j.tibtech.2019.04.006
关键词
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资金
- Australian Research Council Training Centre for Personalised Therapeutics Technologies [IC170100016]
- Foundation for Children [EOI. 2016-081]
- John Stocker Fellowship
- Science and Industry Endowment Fund [PF16-072]
- Commonwealth Scientific and Industrial Research Organisation, Probing Biosystem, Future Science Platform
Therapeutic options for neurological disorders currently remain limited. The intrinsic complexity of the brain architecture prevents potential therapeutics from reaching their cerebral target, thus limiting their efficacy. Recent advances in microfluidic technology and organ-on-chip systems have enabled the development of a new generation of in vitro platforms that can recapitulate complex in vivo microenvironments and physiological responses. In this context, microfluidic-based in vitro models of the blood-brain barrier (BBB) are of particular interest as they provide an innovative approach for conducting research related to the brain, including modeling of neurodegenerative diseases and high-throughput drug screening. Here, we present the most recent advances in BBB-on-chip devices and examine validation steps that will strengthen their future applications.
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