期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 117, 期 -, 页码 13-26出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2019.05.010
关键词
Microfluidic lab-on-a-chip; Single cell analysis; Cancer biology; Cancer diagnosis; Cancer therapy; Cancer research
资金
- National Institute of Allergy and Infectious Disease of the NIH [R21AI107415]
- U.S. NSF-PREM program [DMR 1827745]
- Philadelphia Foundation
- Medical Center of the Americas Foundation
- National Institute of General Medical Sciences of the NIH [SC2GM105584]
- NIH RCMI Pilot grant
- University of Texas at El Paso
- University of Texas (UT) System
Understanding molecular, cellular, genetic and functional heterogeneity of tumors at the single-cell level has become a major challenge for cancer research. The microfluidic technique has emerged as an important tool that offers advantages in analyzing single-cells with the capability to integrate time-consuming and labor-intensive experimental procedures such as single-cell capture into a single microdevice at ease and in a high-throughput fashion. Single-cell manipulation and analysis can be implemented within a multi-functional microfluidic device for various applications in cancer research. Here, we present recent advances of microfluidic devices for single-cell analysis pertaining to cancer biology, diagnostics, and therapeutics. We first concisely introduce various microfluidic platforms used for single-cell analysis, followed with different microfluidic techniques for single-cell manipulation. Then, we highlight their various applications in cancer research, with an emphasis on cancer biology, diagnosis, and therapy. Current limitations and prospective trends of microfluidic single-cell analysis are discussed at the end. (C) 2019 Elsevier B.V. All rights reserved.
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