期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 16, 期 3, 页码 318-334出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871520615666150803125121
关键词
Antitumor drugs; chemoresistance; stomach; treatment; tumor
资金
- Instituto de Salud Carlos III, FIS [PI1100337]
- Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica
- European Regional Development Fund (ERDF) [SAF2010-15517]
- Fundacion Mutua Madrilena
- Junta de Castilla y Leon, Spain [SA015U13, BIO/SA64/13, BIO/SA65/13, BIO/SA52/15]
- Junta de Catilla y Leon
- Fondo Social Europeo [EDU/858/2013]
Although surgical resection is the standard curative therapy for gastric cancer, these tumors are often diagnosed at an advanced stage, when surgery is not recommended. Alternative treatments such as radiotherapy and chemotherapy achieve only very modest results. There is therefore an urgent need to advance in this field of oncologic gastroenterology. The poor response of gastric cancer to chemotherapy is usually due to a combination of mechanisms of chemoresistance (MOC), which may include a reduction in drug uptake (MOC-1a), enhanced drug efflux (MOC-1b), a reduced proportion of active agents in tumor cells due to a reduction in pro-drug activation or an enhancement in drug inactivation (MOC-2), changes in the expression/function of the molecular targets of anticancer drugs (MOC-3), an enhanced ability of cancer cells to repair anticancer drug-induced DNA damage (MOC-4), and decreased expression/function of pro-apoptotic factors or up-regulation of anti-apoptotic genes (MOC-5). Two major goals of modern pharmacology aimed at overcoming this situation are the prediction of a lack of response to chemotherapy and the identification of the underlying mechanisms accounting for primary or acquired refractoriness to anticancer drugs. These are important issues if we are to select the best pharmacological regime for each patient and develop novel strategies to overcome chemoresistance. The present review reports updated information regarding the mechanisms of chemoresistance (from MOC-1 to MOC-5) in gastric cancer, the advances made in the prediction of the failure of chemotherapeutic treatment, and novel strategies based on gene therapy currently being developed to treat these tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据