Palladium-catalyzed direct ortho C-X bond construction via C-H activation of azobenzenes: Synthesis of (E)-1,2-b(2,6-dibromo(chloro)-phenyl)diazene

A palladium-catalyzed direct C-X bond formation of azobenzenes with 1,3-dibromo-5,5-dimethylhydantoin or trichloro isocyanuric acid via C-H activation has been developed. The reaction could proceed smoothly under an air atmosphere at 110 degrees C in the presence of Pd(Ph3P)(4) in DCE and 13 examples of products were obtained. (C) 2019 Elsevier Ltd. All rights reserved.