期刊
TETRAHEDRON LETTERS
卷 60, 期 25, 页码 1667-1670出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.05.043
关键词
2-Acyl thiazoles; 2-Acyl benzothiazoles; Grignard reagents; Acylation
资金
- Natural Science Foundation of Jiangsu Province [BK20171184]
- Jiangsu Planned Projects for Postdoctoral Research Funds [1701132C]
- Technology Plan Projects of Xuzhou [KC17091]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX18-2203]
A convenient and efficient strategy for the synthesis of 2-acyl benzothiazoles/thiazoles has been developed. The treatment of benzothiazole/thiazole with allylic Grignard reagents readily generates the corresponding 2-Grignard reagents, which is followed by a reaction with N,N'-carbonyldiimidazole activated carboxylic acids to afford various 2-acyl benzothiazoles/thiazoles products. The synthetic method is applicable to a wide array of carboxylic acids and allows easy access to 2-acyl benzothiazoles/thiazoles with considerable yields under mild reaction conditions. (C) 2019 Elsevier Ltd. All rights reserved.
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