期刊
TETRAHEDRON LETTERS
卷 60, 期 20, 页码 1393-1396出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.04.034
关键词
Penicillium sp. ZZ486A; Marine-derived fungus; Penibishexahydroxanthone A; Proangiogenesis
资金
- National Natural Science Foundation of China [81773587]
Penibishexahydroxanthone A, a new hexahydroxanthone homodimer with a rare highly oxidized hexacyclic framework, was identified from the marine-derived Penicillium sp. ZZ486A. Its structure was determined by a combination of extensive NMR spectroscopical analyses, HRESIMS data, ECD calculation, and single crystal X-ray diffraction analysis. Penibishexahydroxanthone A showed in vivo activity in promoting angiogenesis in a dose-dependent manner by rescuing VRI-induced vascular insufficiency in zebrafish. This study is the first report of the proangiogenic activity of hexahydroxanthones. (C) 2019 Elsevier Ltd. All rights reserved.
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