期刊
TALANTA
卷 195, 期 -, 页码 281-289出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2018.11.066
关键词
BODIPY; Fluorescent probe; Cysteine; Homocysteine
资金
- National Natural Science Foundation of China [21372063, 21702046, 51702086]
- China Postdoctoral Science Foundation [2018M632757]
Biothiols, such as glutathione (GSH), homocysteine (Hcy) and cysteine (Cys), are important biomarkers and play crucial roles in many physiological processes. Thus, the detection of biothiols is highly important for early diagnosis of diseases and evaluation of disease progression. Herein, new types of BODIPY-based fluorescent probes (probe 1, probe 2 and probe 3) capable of cysteine (Cys)/homocysteine (Hcy) sensing with high selectivity over other amino acids were developed. In addition, we further studied the influence of different electronegativity substituents on these probes to sensing Cys/Hcy. Ultimately, we concluded that the electron withdrawing group on probe 1 can accelerate the probe response to Cys/Hcy, and probe 1 was successfully applied for selective imaging Cys/Hcy in living cells.
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