A review on nanostructured carbon quantum dots and their applications in biotechnology, sensors, and chemiluminescence

Carbon quantum dots (CQDs) are a member of carbon nanostructures family which have received increasing attention for their photoluminescence (PL), physical and chemical stability and low toxicity. The classical semiconductor quantum dots (QDs) are semiconductor particles that are able to emit fluorescence by excitation. The CQDs is mainly referred to photoluminescent carbon nanoparticles less than 10 nm, with surface modification or functionalization. Contrary to other carbon nanostructures, CQDs can be synthesized and functionalized fast and easily. The fluorescence origin of the CQDs is a controversial issue which depends on carbon source, experimental conditions, and functional groups. However, PL emissions originated from conjugated pi-domains and surface defects have been proposed for the PL emission mechanisms of the CQDs. These nanostructures have been used as nontoxic alternatives to the classical heavy metals containing semiconductor QDs in some applications such as in-vivo and in-vitro bio-imaging, drug delivery, photosensors, chemiluminescence (CL), and etc. This paper will introduce CQDs, their structure, and PL characteristics. Recent advances of the application of CQDs in biotechnology, sensors, and CL is comprehensively discussed.