Palladium-Catalyzed Regioselective Heck-Suzuki-Miyaura Cascade Cyclization for the Synthesis of Trisubstituted Arylideneisoquinolinones

An Ugi four-component reaction was used to construct propargylamide starting materials for a subsequent domino Heck-Suzuki-Miyaura cross-coupling reaction to give derivatives of 4-benzylidene-1-oxo-3,4-dihydro-1H-isoquinoline.