期刊
SYNLETT
卷 30, 期 8, 页码 951-954出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1612427
关键词
L-selectride; pyridine; anisole; chemoselective; demethylation
资金
- Hoansha Foundation
A chemoselective demethylation method for various methoxypyridine derivatives has been developed. Treatment of 4-methoxypyridine with L-selectride in THF for 2 h at reflux temperature afforded 4-hydroxypyridine in good yield; no reaction to anisole occurred. The utility of our method was demonstrated by the efficient synthesis of the metabolic substances of the antiulcer agent omeprazole. Chemoselective demethylation at the site of 3,5-dimethyl-4-methoxypyridine in the presence of 4-methoxybenzimidazole was achieved.
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