期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 214, 期 -, 页码 79-85出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2019.02.012
关键词
Amikacin; Antibiotics; IR; Raman; SERS; DFT
类别
资金
- STAR-UBB (Babes-Bolyai University) [36971/22.11.2017]
Amikacin, a molecule formed by two glucosamine rings linked by alpha-linkages through a central deoxystreptamine, is an antibiotic often used in clinical treatments, with a special attention in the pediatric cases, due to the physiological activity of their renal system. In spite of its extensive use, no detailed information about the vibrational features of the molecule is available in the literature. Thus, in this study we performed a comprehensive vibrational investigation of amikacin from both an experimental and theoretical point of view. Raman and IR spectroscopy combined with DFT calculations conducted to a complete vibrational characterization of the molecule, with the assignment of the vibrational modes. Moreover, SERS spectrum was recorded and analyzed and provided information about the adsorption behavior of the amikacin on the silver nanoparticles surface. (C) 2019 Elsevier B.V. All rights reserved.
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