期刊
ANNUAL REVIEW OF PUBLIC HEALTH, VOL 37
卷 37, 期 -, 页码 17-32出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-publhealth-032315-021402
关键词
direct effects; indirect effects; mechanism; pathway analysis
资金
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R56ES017876, R01ES017876] Funding Source: NIH RePORTER
- NIEHS NIH HHS [ES017876] Funding Source: Medline
This article provides an overview of recent developments in mediation analysis, that is, analyses used to assess the relative magnitude of different pathways and mechanisms by which an exposure may affect an outcome. Traditional approaches to mediation in the biomedical and social sciences are described. Attention is given to the confounding assumptions required for a causal interpretation of direct and indirect effect estimates. Methods from the causal inference literature to conduct mediation in the presence of exposure-mediator interactions, binary outcomes, binary mediators, and case-control study designs are presented. Sensitivity analysis techniques for unmeasured confounding and measurement error are introduced. Discussion is given to extensions to time-to-event outcomes and multiple mediators. Further flexible modeling strategies arising from the precise counterfactual definitions of direct and indirect effects are also described. The focus throughout is on methodology that is easily implementable in practice across a broad range of potential applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据