期刊
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 67
卷 67, 期 -, 页码 131-152出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-arplant-043015-111648
关键词
cheminformatics; comparative genomics; damage preemption; damage repair; directed overflow; metabolomics
资金
- Div Of Molecular and Cellular Bioscience [1153413] Funding Source: National Science Foundation
It is increasingly clear that (a) many metabolites undergo spontaneous or enzyme-catalyzed side reactions in vivo, (b) the damaged metabolites formed by these reactions can be harmful, and (c) organisms have biochemical systems that limit the buildup of damaged metabolites. These damage-control systems either return a damaged molecule to its pristine state (metabolite repair) or convert harmful molecules to harmless ones (damage preemption). Because all organisms share a core set of metabolites that suffer the same chemical and enzymatic damage reactions, certain damage-control systems are widely conserved across the kingdoms of life. Relatively few damage reactions and damage-control systems are well known. Uncovering new damage reactions and identifying the corresponding damaged metabolites, damage-control genes, and enzymes demands a coordinated mix of chemistry, metabolomics, cheminformatics, biochemistry, and comparative genomics. This review illustrates the above points using examples from plants, which are at least as prone to metabolite damage as other organisms.
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