4.8 Article

Multifarious Transit Gates for Programmable Delivery of Bio-functionalized Matters

期刊

SMALL
卷 15, 期 28, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201901105

关键词

biofunctionalization; micromagnets; microrobotic particles; on-chip arrays; programmable gating

资金

  1. National Research Foundation of Korea [2018R1A5A1025511]
  2. Max Planck Society
  3. Alexander von Humboldt Foundation
  4. National Research Foundation of Korea [2018R1A5A1025511] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Programmable delivery of biological matter is indispensable for the massive arrays of individual objects in biochemical and biomedical applications. Although a digital manipulation of single cells has been implemented by the integrated circuits of micromagnetophoretic patterns with current wires, the complex fabrication process and multiple current operation steps restrict its practical application for biomolecule arrays. Here, a convenient approach using multifarious transit gates is proposed, for digital manipulation of biofunctionalized microrobotic particles that can pass through the local energy barriers by a time-dependent pulsed magnetic field instead of multiple current wires. The multifarious transit gates including return, delay, and resistance linear gates, as well as dividing, reversed, and rectifying T-junction gates, are investigated theoretically and experimentally for the programmable manipulation of microrobotic particles. The results demonstrate that, a suitable angle of the gating field at a suitable time zone is crucial to implement digital operations at integrated multifarious transit gates along bifurcation paths to trap microrobotic particles in specific apartments, paving the way for flexible on-chip arrays of biomolecules and cells.

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