期刊
ANNUAL REVIEW OF PHYSIOLOGY, VOL 78
卷 78, 期 -, 页码 481-504出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-021115-105238
关键词
microbiota; lung; 16S rRNA; culture independent; microbial ecology; pulmonary
类别
资金
- NCATS NIH HHS [UL1 TR000433] Funding Source: Medline
- NHLBI NIH HHS [L30 HL120241, T32 HL007749, K23 HL130641, R01 HL114447] Funding Source: Medline
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000433] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007749, R01HL114447, K23HL130641] Funding Source: NIH RePORTER
Although the notion that the normal lung is free from bacteria remains common in textbooks, it is virtually always stated without citation or argument. The lungs are constantly exposed to diverse communities of microbes from the oropharynx and other sources, and over the past decade, novel culture-independent techniques of microbial identification have revealed that the lungs, previously considered sterile in health, harbor diverse communities of microbes. In this review, we describe the topography and population dynamics of the respiratory tract, both in health and as altered by acute and chronic lung disease. We provide a survey of current techniques of sampling, sequencing, and analysis of respiratory microbiota and review technical challenges and controversies in the field. We review and synthesize what is known about lung microbiota in various diseases and identify key lessons learned across disease states.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据