期刊
ANNUAL REVIEW OF PHYSIOLOGY, VOL 78
卷 78, 期 -, 页码 415-435出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-021115-105423
关键词
ROMK; BK; SK3; KCa2.3; Kir4.1; Kir5.1
类别
资金
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK093501, R01DK063049, R01DK054231] Funding Source: NIH RePORTER
- NIDDK NIH HHS [R01 DK063049, DK093501, DK 63049, R01 DK093501, DK54231] Funding Source: Medline
More than two dozen types of potassium channels, with different biophysical and regulatory properties, are expressed in the kidney, influencing renal function in many important ways. Recently, a confluence of discoveries in areas from human genetics to physiology, cell biology, and biophysics has cast light on the special function of five different potassium channels in the distal nephron, encoded by the genes KCNJ1, KCNJ10, KCNJ16, KCNMA1, and KCNN3. Research aimed at understanding how these channels work in health and go awry in disease has transformed our understanding of potassium balance and provided new insights into mechanisms of renal sodium handling and the maintenance of blood pressure. This review focuses on recent advances in this rapidly evolving field.
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