期刊
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11
卷 11, 期 -, 页码 365-393出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-012615-044241
关键词
eosinophilic esophagitis; atopy; barrier dysfunction; epithelial inflammation; fibrosis
类别
资金
- NHLBI NIH HHS [T32 HL007752] Funding Source: Medline
- NIAID NIH HHS [R37 AI045898, R01 AI080581, U19 AI070235, T32 AI060515, R01 AI057803, U19 AI066738, U54 AI117804] Funding Source: Medline
- NIDDK NIH HHS [R01 DK076893, P30 DK078392, R01 DK067255] Funding Source: Medline
Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disease of the esophagus with clinical symptoms derived from esophageal dysfunction. The etiology of EoE is now being elucidated, and food hypersensitivity is emerging as the central cornerstone of disease pathogenesis. Herein, we present a thorough picture of the current clinical, pathologic, and molecular understanding of the disease with a focus on disease mechanisms.
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