期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 70
卷 70, 期 -, 页码 255-278出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-102215-095308
关键词
phospholipids; lipid A; lipopolysaccharide; LPS; commensals; outer membrane vesicles; vaccines
类别
资金
- NIAID NIH HHS [R01 AI064184, R21 AI119879] Funding Source: Medline
- NIGMS NIH HHS [F32 GM113488] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI076322, R21AI119879, R01AI064184] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [F32GM113488] Funding Source: NIH RePORTER
Determining the chemical composition of biological materials is paramount to the study of natural phenomena. Here, we describe the composition of model gram-negative outer membranes, focusing on the predominant assembly, an asymmetrical bilayer of lipid molecules. Wealso give an overview of lipid biosynthetic pathways and molecular mechanisms that organize this material into the outer membrane bilayer. An emphasis is placed on the potential of these pathways as targets for antibiotic development. We discuss deviations in composition, through bacterial cell surface remodeling, and alternative modalities to the asymmetric lipid bilayer. Outer membrane lipid alterations of current microbiological interest, such as lipid structures found in commensal bacteria, are emphasized. Additionally, outer membrane components could potentially be engineered to develop vaccine platforms. Observations related to composition and assembly of gram-negative outer membranes will continue to generate novel discoveries, broaden biotechnologies, and reveal profound mysteries to compel future research.
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