期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 296, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2019.04.053
关键词
Fentanyl; Glove based-sensor; Opioids; On-site drug screening; Electrochemical; Sensors
资金
- Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense [HDTRA 1-16-1-0013]
- National Institutes of Health [R41DA044905]
- CSIRO
- UCSD Center of Wearable Sensors (CWS)
Rapid, on-site detection of fentanyl is of critical importance, as it is an extremely potent synthetic opioid that is prone to abuse. Here we describe a wearable glove-based sensor that can detect fentanyl electrochemically on the fingertips towards decentralized testing for opioids. The glove-based sensor consists of flexible screen-printed carbon electrodes modified with a mixture of multiwalled carbon nanotubes and a room temperature ionic liquid, 4-(3-butyl-1-imidazolio)-1-butanesulfonate. The sensor shows direct oxidation of fentanyl in both liquid and powder forms with a detection limit of 10 mu M using square-wave voltammetry. The Lab-on-a-Glove sensors, combined with a portable electrochemical analyzer, provide wireless transmission of the measured data to a smartphone or tablet for further analysis. The integrated sampling and sensing methodology on the thumb and index fingers, respectively, enables rapid screening of fentanyl in the presence of a mixture of cutting agents and offers considerable promise for timely point-of-need screening for first responders. Such a glove-based swipe, scan, sense, and alert strategy brings chemical analytics directly to the user's fingertips and opens new possibilities for detecting substances of abuse in emergency situations.
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