期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 287, 期 -, 页码 1-8出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2019.02.023
关键词
Quantum dots; Chiral nano ZnTPyP; Amino acids, on-off-on; Chiral recognition
资金
- National Natural Science Foundation of China [21576297, 21776321, 21705076, 21776259, 21476270]
- Key Projects of Technological Innovation of Hubei Province [2016ACA138]
- Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei province (South-Central University for Nationalities) [2015ZD001, 2015ZD002, 2015ZY006]
- Talented Youth Cultivation Program from the Fundamental Research Funds for the Central Universities, South-Central University for Nationalities [CRZ18002]
Interests in the recognition of chiral amino acids have grown tremendously in recent years, particularly in the fields of food analysis and pharmaceutical studies. Herein, an innovative on-off-on fluorescent assay has been developed for the sensitive and selective determination of chiral Proline (Pro), Lysine (Lys), and Serine (Ser). This detection platform is constructed by exploiting the fluorescence quenching ability of chiral self-assembly zinc 5, 10, 15, 20-tetra(4-pyridyl)-21H-23H-porphine (ZnTPyP) to CdTe quantum dots (CdTe QDs). CdTe QDs can act as signal switches whose fluorescence signals can effectively quenched by chiral nano ZnTPyP and then restored in the presence of enantiomer amino acids. The coupling use of CdTe QDs and chiral nano ZnTPyP also permits quantitative analysis of D-Pro, D-Lys, L-Ser with detection limits of 4.46x10(-10) mol L-1, 7.13x10(-11) mol L-1, and 3.35x10(-11) mol L-1, respectively. The approach is also suitable for the effective detection of the three amino acids in complex biological matrices. This rapid, robust and reliable strategy for recognizing enantiomer amino acids has not been reported. The proposed method can be a powerful and valuable technology in the areas of drug discovery and food chemistry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据