期刊
ANNUAL REVIEW OF MEDICINE, VOL 67
卷 67, 期 -, 页码 355-374出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-051914-022120
关键词
autoimmunity; inflammation; kinase inhibitors; cytoskeletal reorganization; interleukin 17; interleukin 21
资金
- NIAMS NIH HHS [R01 AR064883] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR064883] Funding Source: NIH RePORTER
The Rho kinases, or ROCKs, are a family of serine-threonine kinases that serve as key downstream effectors for Rho GTPases. The ROCKs are increasingly recognized as critical coordinators of a tissue response to injury due to their ability to modulate a wide range of biological processes. Dysregulated ROCK activity has been implicated in several human pathophysiological conditions ranging from cardiovascular and renal disorders to fibrotic diseases. In recent years, an important role for the ROCKs in the regulation of immune responses is also being uncovered. We provide an overview of the role of the ROCKs in immune cells and discuss studies that highlight the emerging involvement of this family of kinases in the pathogenesis of autoimmune diseases. Given the potential promise of the ROCKs as therapeutic targets, we also outline the approaches that could be employed to inhibit the ROCKs in autoimmune disorders.
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