期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 34
卷 34, 期 -, 页码 93-119出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-032713-120204
关键词
dendritic cell; common dendritic progenitor; lineage commitment; transcription factors
类别
资金
- NATIONAL CANCER INSTITUTE [P30CA091842, F31CA189491] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [F30DK108498] Funding Source: NIH RePORTER
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [F31 CA189491, P30 CA091842] Funding Source: Medline
- NIDDK NIH HHS [F30 DK108498] Funding Source: Medline
The dendritic cells (DCs) of the immune system function in innate and adaptive responses by directing activity of various effector cells rather than serving as effectors themselves. DCs and closely related myeloid lineages share expression of many surface receptors, presenting a challenge in distinguishing their unique in vivo functions. Recent work has taken advantage of unique transcriptional programs to identify and manipulate murine DCs in vivo. This work has assigned several nonredundant in vivo functions to distinct DC lineages, consisting of plasmacytoid DCs and several subsets of classical DCs that promote different immune effector modules in response to pathogens. In parallel, a correspondence between human and murine DC subsets has emerged, underlying structural similarities for the DC lineages between these species. Recent work has begun to unravel the transcriptional circuitry that controls the development and diversification of DCs from common progenitors in the bone marrow.
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