期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 34
卷 34, 期 -, 页码 479-510出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-032414-112008
关键词
lipid antigens; metabolite antigens; antigen presentation; innate-like T cells; natural killer T cells; mucosal-associated invariant T cells; T cell receptor; infectious diseases; autoimmune diseases; tumor immunity
类别
CD1- and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic antigens, such as lipids and small metabolites, and account for a major fraction of circulating and tissue-resident T cells. They represent a readily activated, long-lasting population of effector cells and contribute to the early phases of immune response, orchestrating the function of other cells. This review addresses the main aspects of their immunological functions, including antigen and T cell receptor repertoires, mechanisms of nonpeptidic antigen presentation, and the current evidence for their participation in human and experimental diseases.
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