期刊
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 17
卷 17, 期 -, 页码 17-43出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genom-083115-022339
关键词
CTCF; cohesin; chromosome conformation capture; genome folding; TAD; loop extrusion; gene regulation
资金
- MRC [MC_U120027516] Funding Source: UKRI
- Medical Research Council [MC_U120027516] Funding Source: Medline
- Wellcome Trust [WT099276/Z/12/Z] Funding Source: Medline
Genome function, replication, integrity, and propagation rely on the dynamic structural organization of chromosomes during the cell cycle. Genome folding in interphase provides regulatory segmentation for appropriate transcriptional control, facilitates ordered genome replication, and contributes to genome integrity by limiting illegitimate recombination. Here, we review recent high-resolution chromosome conformation capture and functional studies that have informed models of the spatial and regulatory compartmentalization of mammalian genomes, and discuss mechanistic models for how CTCF and cohesin control the functional architecture of mammalian chromosomes.
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