期刊
ANNUAL REVIEW OF GENETICS, VOL 50
卷 50, 期 -, 页码 571-594出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120215-035011
关键词
reporter; actuator; effector; transgene expression; viral vector; optogenetics; chemogenetics
资金
- MRC [G0700888] Funding Source: UKRI
- Medical Research Council [G0700888, G0701225] Funding Source: Medline
- NIDA NIH HHS [K08 DA036657] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Genetically encoded tools for visualizing and manipulating neurons in vivo have led to significant advances in neuroscience, in large part because of the ability to target expression to specific cell populations of interest. Current methods enable targeting based on marker gene expression, development, anatomical projection pattern, synaptic connectivity, and recent activity as well as combinations of these factors. Here, we review these methods, focusing on issues of practical implementation as well as areas for future improvement.
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