期刊
SEMINARS IN IMMUNOLOGY
卷 41, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2019.03.004
关键词
NK cells; ILC1; NK cell receptors; Cancer therapy; Immune-surveillance; Immune checkpoints; Adoptive NK cell therapy
类别
资金
- Fondazione Cariplo [2015/0603]
- Associazione Italiana per la Ricerca sul Cancro [IG 2018-21567, IG 2017-20312, 5x1000-21147]
- Fondazione Roche (Progetto Roche per la Ricerca 2017)
- Intramural Research Funding of Istituto Clinico Humanitas
- Fondazione Umberto Veronesi [2017-1464, 2018-1974, 2018-1914]
Natural Killer (NK) cells are innate lymphocytes able to mediate immune-surveillance and clearance of viral infected and tumor-transformed cells. Growing experimental and clinical evidence highlighted a dual role of NK cells either in the control of cancer development/progression or in promoting the onset of immune-suppressant tumor microenvironments. Indeed, several mechanisms of NK cell-mediated tumor escape have been described and these includes cancer-induced aberrant expression of activating and inhibitory receptors (i.e. NK cell immune checkpoints), impairments of NK cell migration to tumor sites and altered NK cell effector-functions. These phenomena highly contribute to tumor progression and metastasis formation. In this review, we discuss the latest insights on those NK cell receptors and related molecules that are currently being implemented in clinics either as possible prognostic factors or therapeutic targets to unleash NK cell anti-tumor effector-functions in vivo. Moreover, we address here the major recent advances in regard to the genetic modification and ex vivo expansion of anti-tumor specific NK cells used in innovative adoptive cellular transfer approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据