4.8 Article

Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

Jan Mauer et al.

NATURE (2017)

Article Multidisciplinary Sciences

m6A modulates haematopoietic stem and progenitor cell specification

Chunxia Zhang et al.

NATURE (2017)

Article Multidisciplinary Sciences

Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice

Megumi Kanasaki et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling

Fanny Langlet et al.

Article Biochemistry & Molecular Biology

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

Maia Vinogradova et al.

NATURE CHEMICAL BIOLOGY (2016)

Review Cell Biology

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

Takeshi Inagaki et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Review Nutrition & Dietetics

Relationships between Rodent white Adipose Fat Pads and Human white Adipose Fat Depots

Daniella E. Chusyd et al.

FRONTIERS IN NUTRITION (2016)

Article Biochemistry & Molecular Biology

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

Xiao Wang et al.

Article Cell & Tissue Engineering

m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

Tong Chen et al.

CELL STEM CELL (2015)

Article Medicine, General & Internal

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

Melina Claussnitzer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Biochemical Research Methods

CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites

Yuki Naito et al.

BIOINFORMATICS (2015)

Article Biochemical Research Methods

HTSeq-a Python framework to work with high-throughput sequencing data

Simon Anders et al.

BIOINFORMATICS (2015)

Article Biochemistry & Molecular Biology

Meclofenamic acid selectively inhibits FTO demethylation of m(6)A over ALKBH5

Yue Huang et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

Synthesis of a FTO Inhibitor with Anticonvulsant Activity

Guanqun Zheng et al.

ACS CHEMICAL NEUROSCIENCE (2014)

Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

Article Multidisciplinary Sciences

N6-methyladenosine-dependent regulation of messenger RNA stability

Xiao Wang et al.

NATURE (2014)

Review Endocrinology & Metabolism

Adipose tissue browning and metabolic health

Alexander Bartelt et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

Article Endocrinology & Metabolism

FTO Deficiency Induces UCP-1 Expression and Mitochondrial Uncoupling in Adipocytes

D. Tews et al.

ENDOCRINOLOGY (2013)

Review Cell Biology

Adaptive thermogenesis in adipocytes: Is beige the new brown?

Jun Wu et al.

GENES & DEVELOPMENT (2013)

Article Chemistry, Medicinal

Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)

WeiShen Aik et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

Review Biochemistry & Molecular Biology

Brown and beige fat: development, function and therapeutic potential

Matthew Harms et al.

NATURE MEDICINE (2013)

Review Cell Biology

FOXOs: signalling integrators for homeostasis maintenance

Astrid Eijkelenboom et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Role for the obesity-related FTO gene in the cellular sensing of amino acids

Pawan Gulati et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell Biology

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

Ana Ortega-Molina et al.

CELL METABOLISM (2012)

Article Chemistry, Medicinal

Discovery of Novel Tubulin Inhibitors via Structure-Based Hierarchical Virtual Screening

Ran Cao et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Chemistry, Medicinal

ZINC: A Free Tool to Discover Chemistry for Biology

John J. Irwin et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Chemistry, Medicinal

Life Beyond Kinases: Structure-Based Discovery of Sorafenib as Nanomolar Antagonist of 5-HT Receptors

Xingyu Lin et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Article Chemistry, Multidisciplinary

Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

Baoen Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Multidisciplinary Sciences

FTO genotype is associated with phenotypic variability of body mass index

Jian Yang et al.

NATURE (2012)

Article Multidisciplinary Sciences

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Dan Dominissini et al.

NATURE (2012)

Article Biochemical Research Methods

REFMAC5 for the refinement of macromolecular crystal structures

Garib N. Murshudov et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Guifang Jia et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemistry & Molecular Biology

Relationship between blood glucose levels and hepatic Fto mRNA expression in mice

Nicole J. Poritsanos et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Biochemical Research Methods

DEGseq: an R package for identifying differentially expressed genes from RNA-seq data

Likun Wang et al.

BIOINFORMATICS (2010)

Article Biochemical Research Methods

BEDTools: a flexible suite of utilities for comparing genomic features

Aaron R. Quinlan et al.

BIOINFORMATICS (2010)

Article Chemistry, Medicinal

Rapid Context-Dependent Ligand Desolvation in Molecular Docking

Michael M. Mysinger et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2010)

Letter Multidisciplinary Sciences

FTO effect on energy demand versus food intake

John R. Speakman

NATURE (2010)

Article Multidisciplinary Sciences

Crystal structure of the FTO protein reveals basis for its substrate specificity

Zhifu Han et al.

NATURE (2010)

Article Genetics & Heredity

Overexpression of Fto leads to increased food intake and results in obesity

Chris Church et al.

NATURE GENETICS (2010)

Article Biochemistry & Molecular Biology

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

Eric E. Zhang et al.

NATURE MEDICINE (2010)

Article Biochemical Research Methods

TopHat: discovering splice junctions with RNA-Seq

Cole Trapnell et al.

BIOINFORMATICS (2009)

Article Multidisciplinary Sciences

Inactivation of the Fto gene protects from obesity

Julia Fischer et al.

NATURE (2009)

Editorial Material Biochemistry & Molecular Biology

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

Da Wei Huang et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Endocrinology & Metabolism

Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men

Kristina Annerbrink et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2008)

Review Biochemistry & Molecular Biology

The role of FoxO in the regulation of metabolism

D. N. Gross et al.

ONCOGENE (2008)

Article Biotechnology & Applied Microbiology

Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang et al.

GENOME BIOLOGY (2008)

Article Behavioral Sciences

Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice

Daniela Babovic et al.

BEHAVIOURAL BRAIN RESEARCH (2007)

Article Genetics & Heredity

Variation in FTO contributes to childhood obesity and severe adult obesity

Christian Dina et al.

NATURE GENETICS (2007)

Article Chemistry, Medicinal

Benchmarking sets for molecular docking

Niu Huang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Article Biochemical Research Methods

Production and purification of lentiviral vectors

Gustavo Tiscornia et al.

NATURE PROTOCOLS (2006)

Article Chemistry, Medicinal

Physics-based scoring of protein-ligand complexes: Enrichment of known inhibitors in large-scale virtual screening

N Huang et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2006)

Article Biochemistry & Molecular Biology

Virtual screening against metalloenzymes for inhibitors and substrates

JJ Irwin et al.

BIOCHEMISTRY (2005)

Review Chemistry, Medicinal

Hierarchical docking of databases of multiple ligand conformations

DM Lorber et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Virtual screening of chemical libraries

BK Shoichet

NATURE (2004)

Article Biochemistry & Molecular Biology

A highly efficient recombineering-based method for generating conditional knockout mutations

PT Liu et al.

GENOME RESEARCH (2003)

Article Biochemistry & Molecular Biology

A model binding site for testing scoring functions in molecular docking

BQQ Wei et al.

JOURNAL OF MOLECULAR BIOLOGY (2002)