期刊
SCIENCE SIGNALING
卷 12, 期 581, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.aax3521
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资金
- Stockholm University
- Swedish Research Council [2015-02857, 2016-00890]
- Swedish Cancer Foundation [CAN 2017/421]
- Umea University
- Swedish Research Council [2016-00890, 2015-02857] Funding Source: Swedish Research Council
Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of foreign or damaged self-DNA inside the cell and is critical for the outcome of infections, inflammatory diseases, and cancer. Two studies now demonstrate that cGAS activation is regulated by differential subcellular localization through its non-enzymatic, N-terminal domain.
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