期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32
卷 32, 期 -, 页码 649-675出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-111315-124936
关键词
bone angiogenesis; vascular niche; angiocrine factors; hematopoietic stem cells
In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.
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