期刊
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 18
卷 18, 期 -, 页码 235-258出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-081514-123305
关键词
articular cartilage; osteoarthritis; friction and lubrication; boundary lubrication; cartilage lubrication; hydration lubrication; hyaluronan; lubricin; phospholipids; supramolecular synergy
The major synovial joints such as hips and knees are uniquely efficient tribological systems, able to articulate over a wide range of shear rates with a friction coefficient between the sliding cartilage surfaces as low as 0.001 up to pressures of more than 100 atm. No human-made material can match this. The means by which such surfaces maintain their very low friction has been intensively studied for decades and has been attributed to fluid-film and boundary lubrication. Here, we focus especially on the latter: the reduction of friction by molecular layers at the sliding cartilage surfaces. In particular, we discuss such lubrication in the light of very recent advances in our understanding of boundary effects in aqueous media based on the paradigms of hydration lubrication and of the synergism between different molecular components of the synovial joints (namely hyaluronan, lubricin, and phospholipids) in enabling this lubrication.
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