期刊
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 18
卷 18, 期 -, 页码 51-76出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-092115-025322
关键词
transmembrane domains; drug discovery; high-throughput screening; rational design; curvature sensing
资金
- NIGMS NIH HHS [R01 GM103843, R01 GM101279, T32 GM142607, T32 GM008759] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008759, R01GM103843, R01GM101279] Funding Source: NIH RePORTER
The majority of therapeutics target membrane proteins, accessible on the surface of cells, to alter cellular signaling. Cells use membrane proteins to transduce signals into cells, transport ions and molecules, bind cells to a surface or substrate, and catalyze reactions. Newly devised technologies allow us to drug conventionally undruggable regions of membrane proteins, enabling modulation of protein-protein, protein-lipid, and protein-nucleic acid interactions. In this review, we survey the state of the art of high-throughput screening and rational design in drug discovery, and we evaluate the advances in biological understanding and technological capacity that will drive pharmacotherapy forward against unorthodox membrane protein targets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据