期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85
卷 85, 期 -, 页码 103-132出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-060815-014343
关键词
mitochondrial translation; 39S mitoribosomal subunit; 28S mitoribosomal subunit; antibiotics; ribosome evolution; cryo-electron microscopy
Mitochondrial ribosomes (mitoribosomes) perform protein synthesis inside mitochondria, the organelles responsible for energy conversion and adenosine triphosphate production in eukaryotic cells. Throughout evolution, mitoribosomes have become functionally specialized for synthesizing mitochondrial membrane proteins, and this has been accompanied by large changes to their structure and composition. We review recent high-resolution structural data that have provided unprecedented insight into the structure and function of mitoribosomes in mammals and fungi.
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