期刊
SCIENCE
卷 364, 期 6437, 页码 255-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aav7893
关键词
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资金
- Wellcome Trust [095668, 095669, 108726, 205093, 204915]
- European Research Council [694401]
- Simons Foundation [SCGB 325512]
- 4-year Gatsby Foundation Ph.D. studentship
- HHMI Janelia
- Human Frontier Sciences Program
- Marie Curie Action of the EU [656528]
- Marie Curie Actions (MSCA) [656528] Funding Source: Marie Curie Actions (MSCA)
- European Research Council (ERC) [694401] Funding Source: European Research Council (ERC)
Neuronal populations in sensory cortex produce variable responses to sensory stimuli and exhibit intricate spontaneous activity even without external sensory input. Cortical variability and spontaneous activity have been variously proposed to represent random noise, recall of prior experience, or encoding of ongoing behavioral and cognitive variables. Recording more than 10,000 neurons in mouse visual cortex, we observed that spontaneous activity reliably encoded a high-dimensional latent state, which was partially related to the mouse's ongoing behavior and was represented not just in visual cortex but also across the forebrain. Sensory inputs did not interrupt this ongoing signal but added onto it a representation of external stimuli in orthogonal dimensions. Thus, visual cortical population activity, despite its apparently noisy structure, reliably encodes an orthogonal fusion of sensory and multidimensional behavioral information.
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