期刊
RUSSIAN CHEMICAL BULLETIN
卷 68, 期 4, 页码 855-861出版社
SPRINGER
DOI: 10.1007/s11172-019-2496-1
关键词
triterpenoids; alkynes; esterification; betulinic acid; oleanolic acid; ursolic acid; glycyrrhetic acid; cytotoxicity
资金
- Russian Science Foundation [17-74-10204, 17-74-30012]
- Russian Science Foundation [17-74-30012, 17-74-10204] Funding Source: Russian Science Foundation
Pentacyclic triterpene hydroxy acids were transformed into acetylene-containing derivatives: propargyl esters at the carboxy group and O-(hex-5-ynoyl) derivatives at the hydroxy group. The cytotoxicity of the synthesized compounds was examined against HepG2 and Huh7 hepatocarcinoma cells and PC3 prostate cancer cells. The primary analysis of the structureactivity relationships was performed; glycyrrhetic acid derivatives showed the maximum enhancement in the cytotoxic properties upon introduction of an alkyne moiety.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据