期刊
PROTEOMICS
卷 19, 期 10, 页码 -出版社
WILEY
DOI: 10.1002/pmic.201800361
关键词
bioinformatics; mass spectrometry; proteoform; proteoform family; top-down proteomics
资金
- National Institute of General Medical Sciences of the National Institutes of Health (NIH) [R35GM126914, R01GM114292]
- NIH Biotechnology Training Program [T32GM008349]
- NIH Genomic Sciences Training Program [5T32HG002760]
- NIH Chemistry Biology Interface Training Program [T32GM008505]
- NIH [R01GM125991, R01GM118470, R01 GM117058, R01 GM125085, R01HL109810, R01HL096971, R01GM117058, R01GM125085, S10OD018475]
- [NSF/DMR-1644779]
- [P41GM108569]
A proteoform is a defined form of a protein derived from a given gene with a specific amino acid sequence and localized post-translational modifications. In top-down proteomic analyses, proteoforms are identified and quantified through mass spectrometric analysis of intact proteins. Recent technological developments have enabled comprehensive proteoform analyses in complex samples, and an increasing number of laboratories are adopting top-down proteomic workflows. In this review, some recent advances are outlined and current challenges and future directions for the field are discussed.
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