期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 18, 页码 8815-8823出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1812810116
关键词
immune repertoire; Bayesian prediction; biophysics; immune memory; stochastic dynamics
资金
- European Research Council [306312]
- Lewis-Sigler fellowship
- Simons Foundation Mathematical Modeling of Living Systems Grant [400425]
- NSF [PHY-1607611, PHY-1734030]
- European Research Council (ERC) [306312] Funding Source: European Research Council (ERC)
An adaptive agent predicting the future state of an environment must weigh trust in new observations against prior experiences. In this light, we propose a view of the adaptive immune system as a dynamic Bayesian machinery that updates its memory repertoire by balancing evidence from new pathogen encounters against past experience of infection to predict and prepare for future threats. This framework links the observed initial rapid increase of the memory pool early in life followed by a midlife plateau to the ease of learning salient features of sparse environments. We also derive a modulated memory pool update rule in agreement with current vaccine-response experiments. Our results suggest that pathogenic environments are sparse and that memory repertoires significantly decrease infection costs, even with moderate sampling. The predicted optimal update scheme maps onto commonly considered competitive dynamics for antigen receptors.
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