期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 20, 页码 9969-9978出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1818327116
关键词
unconventional memory T cells; regulatory T cells; virtual memory T cells; IL-15; virus infection
资金
- National Institutes of Allergy and Infectious Diseases, NIH [R01 AI087657, R01 AI121129, R01 AI141435, U19 AI100625]
- Diseases of Public Health Importance Training Grant [T32AI007509]
Immunological memory exists so that following infection an expanded population of pathogen-specific lymphocytes can rapidly and efficiently control infection in the case of reexposure. However, in the case of CD8+ T lymphocytes, a population of unconventional CD44+CD122+ virtual memory T cells (T-VM) has been described that possesses many, though not all, features of true memory T cells, without the requirement of first encountering cognate antigen. Here, we demonstrate a role for regulatory T cell-mediated restraint of TVM at least in part through limiting IL-15 trans-presentation by CD11b+ dendritic cells. Further, we show that keeping TVM in check ensures development of functional, antigen-specific true memory phenotype CD8+ T cells that can assist in pathogen control upon reexposure.
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