期刊
POLYMER BULLETIN
卷 77, 期 3, 页码 1343-1357出版社
SPRINGER
DOI: 10.1007/s00289-019-02803-1
关键词
Cross-linking; PVP; Hydrogel; Antileishmanial
The aim of this study was to elaborate a suitable hydrogel to be used as drug carrier for antileishmanial treatment. Therefore, a PVP hydrogel was synthesized using gamma radiation technique. In the first step, PVP, agar and PEG concentrations were modified as a function of dose rate. Then, established polymers were characterized using FTIR, solid-state C-13 NMR and TGA analyses. After that, rheological measurements followed to determine elastic and viscous modulus. Based on these techniques, it was found that synthesized PVP-hydrogels have the structure of a semi-interpenetrated network (SIPN). The sample containing 3% of PEG was selected to test its potential as antileishmanial drug carrier because it had the elastic modulus that fits more the application as wound dressing. As antileishmanial drug carrier, it has been shown that in the presence of hydrogel, the activity of conventional drug (Amphotericin B) on Leishmania promastigotes was markedly improved with an increase in selectivity index from 10.54 to 56.8.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据