期刊
POLYHEDRON
卷 170, 期 -, 页码 12-24出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2019.05.027
关键词
Selenourea; Ferrocene; Enzymology; Cytotoxicity; Free radicals
资金
- Higher Education Commission Islamabad, Pakistan
- Pakistan Academy of Sciences
In this article we have comprehensively reported the synthesis, complete chemical characterization (FTIR, multinuclear NMR, single crystal XRD, CHNS, AAS) and biological applications of seventeen ferrocene incorporated selenoureas. Biological applications include comparative DNA binding studies (with, cyclic voltammetry), antioxidant activities (DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging), anti-inflammatory activities (nitrite inhibition), phase I enzyme inhibition activities (aromatase inhibition), phase II enzyme induction studies (quinone reductase induction) and cytotoxic studies against neuroblastoma (MYCN2 and SK-N-SH), liver cancer (Hepa 1c1c7) breast cancer (MCF-7) and human cervical carcinoma HeLa cells (ATCC (R) CCL-2). All the compounds showed decent structure dependent biological applications. (C) 2019 Elsevier Ltd. All rights reserved.
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