期刊
PEST MANAGEMENT SCIENCE
卷 75, 期 11, 页码 2901-2909出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/ps.5483
关键词
fluralaner; GABA receptor; honeybee; isoxazoline; insecticide
资金
- Fundamental Research Funds for the Central Universities [KYZ201710] Funding Source: Medline
- Ministry of Science and Technology of the People's Republic of China [2017YFD0200900] Funding Source: Medline
- National Natural Science Foundation of China [31871995] Funding Source: Medline
- National Key R & D Program of China [2017YFD0200900] Funding Source: Medline
- Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430073, China [2017009] Funding Source: Medline
- Wuhan Institute of Technology [2017009] Funding Source: Medline
BACKGROUND Fluralaner, a novel pesticide that targets the gamma-aminobutyric acid (GABA) receptor (GABAR) subunit of resistant to dieldrin (RDL), exhibits strong potential to be an insecticide to control agricultural insect pests. However, the risk and action of fluralaner to economic insects, e.g., honeybee Apis mellifera Linnaeus, remains unclear. RESULTS In this study, both oral and contact toxicity of fluralaner to honeybee were found to be 0.13 mu g adult(-1). Abamectin, dieldrin, ethiprole, alpha-endosulfan, fipronil and fluralaner strongly inhibited the GABA-induced current in A. mellifera RDL (AmRDL), expressed in Xenopus laevis oocytes, with median inhibitory concentration (IC50) values of 7.99, 868.1, 27.10, 412.0, 11.21 and 13.59 nM, respectively. The binding free energy and electrophysiological response of AmRDL and insecticides were opposite. The correlation values between toxicity (to A. mellifera) and binding free energy/electrophysiological inhibition (to AmRDL) were at a moderate level. CONCLUSION In conclusion, we report for the first time the notable risk of fluralaner to honeybee in vivo and compared the actions of GABAR-targeted insecticides on the AmRDL receptor. (c) 2019 Society of Chemical Industry
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