期刊
PEPTIDES
卷 115, 期 -, 页码 43-50出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2019.02.009
关键词
Scorpion; Buthus martensii Karsch; Peptides; Therapeutic potential
资金
- National Natural Sciences Foundation of China [81703475]
- Doctor Scientific Research Fund of Henan University of Science and Technology [4020-13480034]
The scorpion Buthus martensii Karsch (BmK) has generated significant interest due to the presence of biologically active peptides in its venom. In the past decade, dozens of different peptides from BmK have been identified. Most of the peptides are neurotoxins and are responsible for the toxicity of BmK venom. Other peptides, including neurotoxins and non-disulfide-bridged peptides, show potential anticancer, antimicrobial, analgesic, and anti-epileptic therapeutic effects. These peptides are attractive candidates for drug development, and peptide derivatives have also been designed to enhance their therapeutic potential, such as ADWX-1 and Kn2-7. In this review, we provide an overview of the most promising peptides found in BmK venom and of modified peptide derivatives showing therapeutic potential.
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