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Reactive oxygen species, cellular redox systems, and apoptosis
Magdalena L. Circu et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity
Alberto Ferri et al.
HUMAN MOLECULAR GENETICS (2010)
Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease
Jinho Kim et al.
HUMAN MOLECULAR GENETICS (2010)
ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2
Steve Pedrini et al.
HUMAN MOLECULAR GENETICS (2010)
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
I. Irrcher et al.
HUMAN MOLECULAR GENETICS (2010)
p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
Ashish Jain et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
Atsushi Tanaka et al.
JOURNAL OF CELL BIOLOGY (2010)
Amyloid-β Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3β in Primary Cultured Hippocampal Neurons
Helena Decker et al.
JOURNAL OF NEUROSCIENCE (2010)
Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice
Ya-Fei Xu et al.
JOURNAL OF NEUROSCIENCE (2010)
A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
Alexandria Lau et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
Jaime N. Guzman et al.
NATURE (2010)
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Masaaki Komatsu et al.
NATURE CELL BIOLOGY (2010)
Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS
Adrian Israelson et al.
NEURON (2010)
Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1
Guido Krebiehl et al.
PLOS ONE (2010)
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
Elena Ziviani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol
Des R. Richardson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
Derek P. Narendra et al.
PLOS BIOLOGY (2010)
The dorsal root ganglion in Friedreich's ataxia
Arnulf H. Koeppen et al.
ACTA NEUROPATHOLOGICA (2009)
Complex I and ATP Content Deficiency in Lymphocytes from Friedreich's Ataxia
Mohammad Mehdi Heidari et al.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES (2009)
Divalent metal transporter 1 is involved in amyloid precursor protein processing and A beta generation
Wei Zheng et al.
FASEB JOURNAL (2009)
Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis
Ruben K. Dagda et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2009)
Correlation of Iron in the Hippocampus with MMSE in Patients with Alzheimer's Disease
Bei Ding et al.
JOURNAL OF MAGNETIC RESONANCE IMAGING (2009)
Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport
Will Stoothoff et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial (vol 7, pg 779, 2008)
L. Lannfelt et al.
LANCET NEUROLOGY (2009)
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
Pei-Chun Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant
Michael Li-Hsuan Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria
Wen Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mitofusin 2: A mitochondria-shaping protein with signaling roles beyond fusion
Olga Martins De Brito et al.
ANTIOXIDANTS & REDOX SIGNALING (2008)
Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane
S. Lucken-Ardjomande et al.
CELL DEATH AND DIFFERENTIATION (2008)
Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1
Claude A. Piantadosi et al.
CIRCULATION RESEARCH (2008)
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
Shih-Ching Lo et al.
EXPERIMENTAL CELL RESEARCH (2008)
Proteomic and oxidative stress analysis in human brain samples of Huntington disease
M. Alba Sorolla et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease
Veerle Bogaerts et al.
HUMAN MUTATION (2008)
Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
Latha Devi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
Protection against hydrogen peroxide-mediated cytotoxicity in Friedreich's ataxia fibroblasts using novel iron chelators of the 2-pyridylcarboxaldehyde isonicotinoyl hydrazone class
C. K. Lim et al.
MOLECULAR PHARMACOLOGY (2008)
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
Heng Du et al.
NATURE MEDICINE (2008)
The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation
Megan Whitnall et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
Xinglong Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease:: a phase IIa, double-blind, randomised, placebo-controlled trial
Lars Lannfelt et al.
LANCET NEUROLOGY (2008)
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content
Kurt J. De Vos et al.
HUMAN MOLECULAR GENETICS (2007)
Mitochondrial ferritin expression in adult mouse tissues
Paolo Santambrogio et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2007)
Localization of α-synuclein to mitochondria within midbrain of mice
Wen-Wei Li et al.
NEUROREPORT (2007)
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
Eva Andres-Mateos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Astroglia overexpressing heme oxygenase-1 predispose co-cultured PC12 cells to oxidative injury
Linyang Song et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2007)
Neuronal apoptosis in neurodegeneration
Masahiro Okouchi et al.
ANTIOXIDANTS & REDOX SIGNALING (2007)
Selective iron chelation in Friedreich ataxia:: biologic and clinical implications
Nathalie Boddaert et al.
BLOOD (2007)
Direct interorganellar transfer of iron from endosome to mitochondrion
Alex D. Sheftel et al.
BLOOD (2007)
Mitochondria as key components of the stress response
Irini Manoli et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2007)
GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2
Abhinav K. Jain et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Cardiolipin: Setting the beat of apoptosis
Francois Gonzalvez et al.
APOPTOSIS (2007)
A new activating role for CO in cardiac mitochondrial biogenesis
Hagit B. Suliman et al.
JOURNAL OF CELL SCIENCE (2007)
Mitochondrial alterations in the spinal cord of patients with sporadic amyotrophic lateral sclerosis
Shoichi Sasaki et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)
PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated keap1-dependent ubiquitin ligase complex
Shih-Ching Lo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
In vivo modulation of the Parkinsonian phenotype by Nrf2
Neal C. Burton et al.
NEUROTOXICOLOGY (2006)
Oxidative damage in Huntington's disease pathogenesis
Susan E. Browne et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration
Patrick Weydt et al.
CELL METABOLISM (2006)
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin et al.
NATURE (2006)
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
Casey M. Clements et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Transcriptional repression of PGC-α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
Libin Cui et al.
CELL (2006)
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
Elisa Greggio et al.
NEUROBIOLOGY OF DISEASE (2006)
Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease
Beisha Tang et al.
HUMAN MOLECULAR GENETICS (2006)
Mitochondrial DNA and ageing
Aleksandra Trifunovic
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2006)
Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated Huntingtin
A Benchoua et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Mitoferrin is essential for erythroid iron assimilation
GC Shaw et al.
NATURE (2006)
Mice lacking alpha-synuclein are resistant to mitochondrial toxins
P Klivenyi et al.
NEUROBIOLOGY OF DISEASE (2006)
Dysregulation of mitochondrial fusion and fission: an emerging concept in neurodegeneration
S Frank
ACTA NEUROPATHOLOGICA (2006)
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
CJ Gloeckner et al.
HUMAN MOLECULAR GENETICS (2006)
Epidemiology of Parkinson's disease
Lonneke M. L. de Lau et al.
LANCET NEUROLOGY (2006)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
A Petit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant Huntingtin
T Milakovic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
KM Strauss et al.
HUMAN MOLECULAR GENETICS (2005)
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease
BI Bae et al.
NEURON (2005)
DJ-1 is present in a large molecular complex in human brain tissue and interacts with α-synuclein
MC Meulener et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Iron trafficking in the mitochondrion: novel pathways revealed by disease
I Napier et al.
BLOOD (2005)
Parkinson-like syndrome induced by continuous MPTP infusion:: Convergent roles of the ubiquitin-proteasome system and α-synuclein
F Fornai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription
MJ Calkins et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress
DJ Moore et al.
HUMAN MOLECULAR GENETICS (2005)
ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease
JW Lustbader et al.
SCIENCE (2004)
Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP
DD Song et al.
EXPERIMENTAL NEUROLOGY (2004)
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
JE Chipuk et al.
SCIENCE (2004)
Mitochondrial effectors in caspase-independent cell death
HK Lorenzo et al.
FEBS LETTERS (2004)
Heme oxygenase expression in human central nervous system disorders
HM Schipper
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Nicastrin, presenilin, APH-1, and PEN-2 form active γ-secretase complexes in mitochondria
CA Hansson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
PE Coskun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release
YS Choo et al.
HUMAN MOLECULAR GENETICS (2004)
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria
J Liu et al.
NEURON (2004)
Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
P Pasinelli et al.
NEURON (2004)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
OPA1 requires mitofusin 1 to promote mitochondrial fusion
S Cipolat et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
RM Canet-Avilés et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Neuroprotective role of the reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice
LM Martins et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Defects in adaptive energy metabolism with CNS-Linked hyperactivity in PGC-1α null mice
JD Lin et al.
CELL (2004)
A specific role of the yeast mitochondrial carriers Mrs3/4p in mitochondrial iron acquisition under iron-limiting conditions
U Mühlenhoff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Familial Parkinson's disease: a hint to elucidate the mechanisms of nigral degeneration
N Hattori et al.
JOURNAL OF NEUROLOGY (2003)
Mechanisms of transcriptional dysregulation in Huntington's disease
R Luthi-Carter et al.
CLINICAL NEUROSCIENCE RESEARCH (2003)
ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes
CMJ Higgins et al.
BMC NEUROSCIENCE (2003)
Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
HK Anandatheerthavarada et al.
JOURNAL OF CELL BIOLOGY (2003)
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
V Bonifati et al.
SCIENCE (2003)
Friedreich's Ataxia: Disease mechanisms, antioxidant and coenzyme Q(10) therapy
JM Cooper et al.
BIOFACTORS (2003)
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
JT Rogers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
DNA binding is required for the apoptogenic action of apoptosis inducing factor
H Ye et al.
NATURE STRUCTURAL BIOLOGY (2002)
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
AV Panov et al.
NATURE NEUROSCIENCE (2002)
Presenilin-1 is located in rat mitochondria
M Ankarcrona et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Deletion of the mitochondrial carrier genes MRS3 and MRS4 suppresses mitochondrial iron accumulation in a yeast frataxin-deficient strain
F Foury et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Dopamine-dependent neurotoxicity of α-synuclein:: A mechanism for selective neurodegeneration in Parkinson disease
J Xu et al.
NATURE MEDICINE (2002)
Altered metabolism of the amyloid β precursor protein is associated with mitochondrial dysfunction in Down's syndrome
J Busciglio et al.
NEURON (2002)
Cytochrome c release from mitochondria proceeds by a two-step process
M Ott et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation.: Possible role in the apoptosis
G Petrosillo et al.
FEBS LETTERS (2001)
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
E Smirnova et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Sticky DNA, a self-associated complex formed at long GAA•TTC repeats in intron 1 of the frataxin gene, inhibits transcriptions
N Sakamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron
DR Richardson et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2001)
PUMA induces the rapid apoptosis of colorectal cancer cells
J Yu et al.
MOLECULAR CELL (2001)
Frataxin: its role in iron metabolism and the pathogenesis of Friedreich's ataxia
E Becker et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2001)
Small Maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:quinone oxidoreductase1 gene
S Dhakshinamoorthy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Oxidants, oxidative stress and the biology of ageing
T Finkel et al.
NATURE (2000)
Mitochondrial respiratory chain disorders I: mitochondrial DNA defects
JV Leonard et al.
LANCET (2000)