期刊
ORGANOMETALLICS
卷 38, 期 20, 页码 3979-3990出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.9b00183
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资金
- National Natural Science Foundation. of China (NSFC) [21790332, 21521002]
- CAS [QYZDJSSWSLH023]
An efficient sequential intramolecular hydroamination/asymmetric hydrogenation reaction under catalysis of a single chiral ruthenium complex or a binary system consisting of achiral gold complex and chiral ruthenium complex has been reported. A diverse range of enantioen-riched benzo-fused N-heterocycles, including 1,2,3,4-tetrahydroquinoline, indoline, and 2,3,4,5-tetrahydro-1H-benzo[b]-azepine derivatives, were obtained from anilino-alkynes in high yields (up to 98%) with moderate to excellent enantioselectivities (up to 98% ee) under mild conditions. This protocol features good functional group tolerance and high atom economy. Furthermore, this catalytic protocol is applicable to gram-scale synthesis of a naturally occurring alkaloid, (-)-Angustureine.
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