4.5 Article

Phosphine-Free Well-Defined Mn(I) Complex-Catalyzed Synthesis of Amine, Imine, and 2,3-Dihydro-1H-perimidine via Hydrogen Autotransfer or Acceptorless Dehydrogenative Coupling of Amine and Alcohol

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ORGANOMETALLICS
卷 38, 期 8, 页码 1815-1825

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AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.9b00131

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资金

  1. SERB, DST [ECR/2016/000108]
  2. DST-INSPIRE [IFA-14-CH-143]
  3. Science and Engineering Research Board, Department of Science and Technology [DST-SERB SB/S2/RJN/004-2015]
  4. CIF
  5. Department of Chemistry IITG
  6. DST-FIST program
  7. Param-Ishan supercomputing facility at IITG

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The application of nontoxic, earth-abundant transition metals in place of costly noble metals is a paramount goal in catalysis and is especially interesting if the air- and moisture-stable ligand scaffold is used. Herein, we report the synthesis of amines/imines directly from alcohol and amines via hydrogen autotransfer or acceptorless dehydrogenation catalyzed by well-defined phosphine-free Mn complexes. Both imines and amines can be obtained from the same set of alcohols and amines using the same catalyst, only by tuning the reaction conditions. The amount and nature of the base are found to be a highly important aspect for the observed selectivity. Both the primary and secondary amines have been employed as substrates for the N-alkylation reaction. As a highlight, we showed the chemoselective synthesis of resveratrol derivatives. Furthermore, the Mn-catalyzed dehydrogenative synthesis of structurally important 2,3-dihydro-1H-perimidines has also been demonstrated. Density functional theory calculations were also carried out to model the reaction path and to calculate the reaction profile.

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