期刊
ORGANOMETALLICS
卷 38, 期 20, 页码 3927-3930出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.9b00112
关键词
-
资金
- National Natural Science Foundation of China [21702184, 21772175]
A Pd-catalyzed dearomative arylvinylation reaction of indoles with N-arylsulfonylhydrazones as coupling partners is developed, which proceeds via a domino sequence involving dearomative carbopalladation, Pd-carbene migratory insertion, and regioselective beta-hydride elimination. A range of 3-vinylindolines bearing vicinal quaternary and tertiary carbon stereocenters is achieved in moderate yields. The enantioselective reaction was established by using a chiral BINOL-based phosphoramidite ligand, which led to the arylvinylation products in good enantiomeric ratios and excellent diastereoselectivities.
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