期刊
ORGANIC LETTERS
卷 21, 期 11, 页码 4345-4349出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01523
关键词
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资金
- Spanish Ministerio de Economia y Competitividad (MINECO/FEDER, UE) [CTQ2015-66954-P]
- MINECO
- Fondo Social Europeo
- European Commission [CIG: CHAAS-304085]
A general method for the construction of seven-membered rings through Pd-catalyzed C(sp(2))-H carbonylation at the remote epsilon-position of gamma-arylpropylamine derivatives, including chiral alpha-amino acids, has been developed using Mo(CO)(6) as the CO source, furnishing richly functionalized benzo[c]azepin-1-one derivatives. The readily removable N-SO2Py protecting/directing group provides high levels of chemo-, regio- and diastereoselectivity. Furthermore, this method is amenable to the postsynthetic modification of complex molecules such as small peptides.
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