期刊
ORGANIC LETTERS
卷 21, 期 12, 页码 4585-4589出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01491
关键词
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资金
- National Key Research and Development Program of China [2018YFD0200100]
- National Natural Science Foundation of China [21732002, 21672117]
In this study, a new C(sp(3))-H monofluoroalkenylation reaction involving cooperative visible-light photoredox catalysis and hydrogen-atom-transfer catalysis to afford products generated by selective hydrogen abstraction and radical-radical cross-coupling was described. This mild, efficient reaction shows high regioselectivity for the alpha-carbon atoms of amines, ethers, and thioethers and thus allows the preparation of monofluoroalkenes bearing various substituents. The reaction was applied to two bioactive molecules, indicating its utility for late-stage monofluoroalkenylation of compounds with inert C(sp(3))-H bonds.
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