期刊
ORGANIC LETTERS
卷 21, 期 10, 页码 3804-3807出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01255
关键词
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资金
- National Natural Science Foundation of China [21572024]
- Jiangsu Key Laboratory of Advanced Catalytic Materials Technology [BM2012110]
- Green Manufacturing Collaborative Innovation Center
A novel three-component reaction of N-hydroxyanilines, enynones, and diazo compounds has been developed via a metal-organo relay catalysis, providing highly functionalized beta-lactams containing two quaternary carbon centers in good yields and with excellent diastereoselectivities. This protocol features a sequential reaction of Rh-catalyzed imine formation, Wolff rearrangement, and benzoylquinine-catalyzed Staudinger cyclization using the stable, benign, and readily available N-hydroxyanilines as the N-resources.
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