期刊
ORGANIC LETTERS
卷 21, 期 11, 页码 3900-3903出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00855
关键词
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资金
- Austrian Science Fund FWF [I1040, P27947, P31691, P28725, P30370]
- Austrian Research Promotion Agency FFG [West Austrian] [BioNMR 858017]
- Austrian Science Fund (FWF) [P31691, P30370, P27947] Funding Source: Austrian Science Fund (FWF)
3-Deazaguanosine (c(3)G) and phosphoramidite derivatives thereof that allow incorporation of this modification into RNA are needed for atomic mutagenesis experiments to explore mechanistic aspects of ribozyme catalysis. Here, we report a practical synthesis for c(3)G phosphoramidites from inexpensive starting materials. The key reaction sequence is a silyl-Hilbert-Johnson nucleosidation followed by Hartwig-Buchwald cross-coupling to achieve the N-2-phenoxyacetyl protected c(3)G nucleoside.
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